ea0084ps3-14-126 | Thyroid Cancer CLINICAL 2 | ETA2022
Ramone Teresa
, Ciampi Raffaele
, Casalini Roberta
, Valetto Angelo
, Bertini Veronica
, Piaggi Paolo
, Elisei Rossella
, Romei Cristina
Background: Human cancer is characterized by the accumulation of somatic alterations including base substitutions, indels, structural rearrangements and somatic copy number alteration (CNA), either gain or loss, of chromosomes that can be responsible either for initiation and/or cancer progression. About 80% of Sporadic Medullary Thyroid Carcinoma (sMTC) harbor RET or RAS somatic alterations with a negative prognostic role for the presence of the RET mutation; a few s...